Edward L. Frome


Oak Ridge National Laboratory Home Contact Information:

P. O. Box 2008, Bldg. 6012 107 Oneida Lane

Oak Ridge, Tennessee 37831-6367 Oak Ridge, TN 37830

United States

Phone: (865) 574-3138 (865) 482-5101

Fax: (865) 574-0680

Email: FromeEL@ornl.gov FromeStat@comcast.net

Web Site http://www.csm.ornl.gov/~frome/ Short Bio

DOE Clearance Level: Q


Ph.D., Emory University, Statistics & Biometry, 1972

M.S., University of Florida, Statistics, 1966

B.S., University of Florida, Physics, 1964

Postdoctoral Fellow, Anesthesiology, Emory University, 1973


Professional Affiliations:

        American Statistical Association [Elected Fellow ]- 1996

        Biometric Society - ENAR

        Radiation Research Society


Professional Experience:

        1971- 2006, Oak Ridge National Laboratory, Computer Science and Mathematics Division, Senior Research Staff/Statistician

        1998- present, Adjunct Professor, University of Tennessee, Department of Statistics

        1986-2003, Adjunct Professor, University of North Carolina, Biostatistics

        1986-1996, Adjunct Associate Professor, University of North Carolina, Biostatistics

        1977-1981, Medical Div. Oak Ridge Associated Universities, Biostatistics Section Leader

        1973-1977, University of Texas at Austin, Assistant Professor, Statistics

        1972-1973, Dept. of Anesthesiology, Emory University, Postdoctoral Fellow

        1969-1972, Dept. of Statistics and Biometry, Emory University, Research Fellow

        1968-1969, Marketing Research Department, Coca-Cola USA

        1966-1968, Medical and Health Sciences Division, Oak Ridge Associated Universities


Other Expertise:

        Associate Editor for The American Statistician, 1983 - 1993.

        Statistical Consultant for Radiation Research Society, 1991 - present.

        Member of the Oak Ridge Reservation Health Effects Subcommittee (ORRHES),of the Agency for Toxic Substances and Disease Registry(ATSDR/CDC) (2000-01 )

        Member of the City of Oak Ridge Environmental Advisory Board (2000-03)

        Member of the Organizing Committee for the Conference on the Analysis and Assessment of Ionizing Radiation from Scientific and Statistical Perspectives sponsored by the American Statistical Association (ASA), 1983 1989. Chairman of 1985 ASA Conference

        Member of the Information Systems Working Group for the DOE Comprehensive Epidemiologic Data Resource (CEDR): 1990 1993.

        Member of the American Statistical Association Committee on Statistics and the Environment: 1986 1998.

        Member of the Statistics Test Panel for Data Management Systems in Genetic Toxicology, sponsored by the US EPA through Integrated Laboratory Systems: 1987 1990.


Summary of Recent and Earlier Research with links to recent work [Visit Here ].


Publications and Recent Technical Reports:

        E. L. Frome and D. P. Frome 2007, "R package SAND "Statistical Analysis Non-Detects"." (available at www.csm.ornl.gov/esh/statoed/ )

        E. L. Frome and P. W. Wambach. 2006. "Statistical Methods for the Analysis of Occupational Exposure Data with Non-Detectable Values." (Manuscript under revision)

        E. L. Frome and P. F. Wambach, (June, 2005),"Statistical Methods and Software for the Analysis of Occupational Exposure Data With Non-Detectable Values" ORNL/TM-2005/52 (http://www.csm.ornl.gov/esh/aoed/)

        Kerr, G.D. , E.L. Frome, W. G. Tankersley, and J. P. Watkins, (2005)"Historical Evaluation of the Film Badge Dosimetry Program at the Y-12 Facility in Oak Ridge, Tennessee: Part 2 Neutron Radiation", ORAUT-OTIB-0045.

        Frome, E. L. and J. Watkins, (2004), Statistical Analysis of Data with Non-detectable Values,ORNL/TM-2004/146. (http://www.csm.ornl.gov/~frome/sand/)

        Frome, E. L., and P. G. Groer, (2004), Individual Dose Adjustment Procedure for Y-12 Dose Reconstruction, ORAUT-TIB-0013, Revision No. 00-A, Oak Ridge Associate Universities, Oak Ridge, Tennessee

        Watkins, J. P., G. D. Kerr, E. L. Frome, W. G. Tankersley, and C. M. West, (2004), Historical Evaluation of the Film Badge Dosimetry Program at the Y-12 Facility in Oak Ridge, Tennessee, ORAU TechnicalReport # 2004-0888. (http://www.orau.gov/cer/reports.htm )

        Frome,E.L. Newman, L.S., Cragle, D.L, Colyer, S.P. and P.F. Wambach (2003)",Identification of an Abnormal Beryllium Lymphocyte Proliferation Test",Toxicology,183:39-56.

        Farris, G. M., Newman, L. S., Frome, E. L., et. al. Detection of Beryllium Sensitivity Using a Flow Cytometric Lymphocyte Proliferation Test: the IMMUNO-BE-LPT, Toxicology: 143, 125-140, 2000.

        Weresczczak, A., Ferber, M., Kirkland, T., Barnes, A., Frome, E., Asymmetric Tensile and Compressive Creep Deformation of Hot-isostatically-pressed Y2O3-Doped-Si3N4. Journal European Ceramic Society. 19(1999): 227-237, 1999

        Frome, E. L., Cragle, D. L., Watkins, J. P., Wing, S., Shy, C. M., Tankersley, W. G., West, C., A mortality study of employees of the nuclear industry in Oak Ridge, Tennessee [published erratum appears in Radiat Res 1997 Sep;148(3):297-8]. Radiation Research. 148(Jul 1997): 64-80, Jul 1997

        Mitchell, T. J., Ostrouchov, G., Frome, E. L., Kerr, G. D. A method for estimating occupational radiation dose to individuals, using weekly dosimetry data. Radiation Research. 147(Feb 1997): 195-207, Feb 1997

        Watkins, J. P., Reagan, J. L., Cragle, D. L., Frome, E. L., West,C.M., Crawford-Brown, D., and Tankersley, W. G., Collection, Validation, and Treatment of Data for a Mortality Study of Nuclear Industry Workers. Applied Occupational and Environmental Hygiene. 12(1997): 195-205, 1997

        Frome, E. L., Smith, M. H., Littlefield, L. G., Neubert, R.L., Colyer, S. P. Statistical methods for the blood beryllium lymphocyte proliferation test. Environmental Health Perspectives. 104 Suppl 5(Oct 1996): 957-68, Oct 1996

        Fry, S. A., Cragle, D. L., Crawford-Brown, D. J., Dupree, E. A., Frome, E. L., et al. , Health and Mortality Among Contractor Employees at US Department of Energy Facilities. Radiation and Public Perception Benefits and Risks, Advances in Chemistry Series.(1995): 239-258, 1995

        Littlefield, L. G., Joiner, E. E, Colyer, S. P., Frome, E. L., Radioprotective Chemicals as Tools for Studying Mechanisms of Radiation-Induced Chromosome Damage in Human Lymphocytes. Chromosomal Alterations, eds. G. Obe and A. T.(1994): 132-139, 1994

        Wing, S., Shy, C. M., Wood, J.L., Wolf, S., Cragle, D.L., Tankersley, W., Frome, E.L., Job factors, radiation and cancer mortality at Oak Ridge National Laboratory: follow-up through 1984 [published erratum appears in Am J Ind Med 1993;23(4):673]. American Journal of Industrial Medicine. 23(Feb 1993): 265-79, Feb 1993

        Littlefield, L.G., Joiner, E. E., Colyer, S. P., Sallam, F., Frome, E. L., Concentration-dependent protection against X-ray-induced chromosome aberrations in human lymphocytes by the aminothiol WR-1065. Radiation Research. 133(Jan 1993): 88-93, Jan 1993

        Ostrouchov, G. and Frome, E. (1993), "A Model Search Procedure for Hierarchical Models", Computational Statistics and Data Analysis, 15, 285-296.

        Generoso, W. M., Cain, K. T., Cornett, C. V., Frome, E. L. Comparison of two stocks of mice in spermatogonial response to different conditions of radiation exposure. Mutation Research. 249(Aug 1991): 301-10, Aug 1991

        Wing, S., Shy, C. M., Wood, J. L., Wolf, S., Cragle, D. L., Frome, E. L. Mortality among workers at Oak Ridge National Laboratory. Evidence of radiation effects in follow-up through 1984 [published errata appear in JAMA 1991 Aug 7;266(5):657 and 1992 Sep 16;268(11):1414] [see comments]. Jama. 265(Mar 1991): 1397-402, Mar 1991

        Frome, E. L., (1991) "Statistical Analysis of Cytogenetic Dose-Response Curves", in Statistical Methods in Toxicological Research, eds. D. Krewski and C. Franklin, Gordon & Breach Science Publications, Inc., 281-298.

        Frome, E. L., Cragle, D. L., McLain, R. W. Poisson regression analysis of the mortality among a cohort of World War II nuclear industry workers. Radiation Research. 123(Aug 1990): 138-52, Aug 1990

        Littlefield, L.G., Sayer, A.M., Frome, E.L. Comparisons of dose-response parameters for radiation-induced acentric fragments and micronuclei observed in cytokinesis-arrested lymphocytes. Mutagenesis. 4(Jul 1989): 265-70, Jul 1989

        Frome, E. L., and Morris, M. D. Evaluating Goodness of Fit of Poisson Regression Models in Cohort Studies. The American Statistician. 43(1989): 144-147, 1989

        Littlefield, L.G., Joiner, E. E., Colyer, S. P., Sayer, A. M., Frome, E. L. Modulation of radiation-induced chromosome aberrations by DMSO, an OH radical scavenger. 1: Dose-response studies in human lymphocytes exposed to 220 kV X-rays. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine. 53(Jun 1988): 875-90, Jun 1988

        Carpenter, A. V., Flanders, W. D., Frome, E. L., Tankersley, W. G., Fry, S. A. Chemical exposures and central nervous system cancers: a case-control study among workers at two nuclear facilities. American Journal of Industrial Medicine. 13(1988): 351-62, 1988

        Carpenter, A. V., Flanders, W. D., Frome, E. L., Cole, P, Fry, S. A. Brain cancer and nonoccupational risk factors: a case-control study among workers at two nuclear facilities. American Journal of Public Health. 77(Sep 1987): 1180-2, Sep 1987

        Witschi, H. P., Smith, L. H., Frome, E. L., Pequet-Goad, M. E., Griest, W. H., Ho, C. H., Guerin, M. R. Skin tumorigenic potential of crude and refined coal liquids and analogous petroleum products. Fundamental and Applied Toxicology. 9(Aug 1987): 297-303, Aug 1987

        Carpenter, A. V., Flanders, W. D., Frome, E. L., Crawford-Brown, D. J., Fry, S. A. CNS cancers and radiation exposure: a case-control study among workers at two nuclear facilities. Journal of Occupational Medicine. 29(Jul 1987): 601-4, Jul 1987

        Lindenschmidt, R. C., Tryka, A. F., Godfrey, G. A., Frome, E. L., Witschi, H. Intratracheal versus intravenous administration of bleomycin in mice: acute effects. Toxicology and Applied Pharmacology. 85(Aug 1986): 69-77, Aug 1986

        Frome, E. L., DuFrain, R. J. Maximum likelihood estimation for cytogenetic dose-response curves. Biometrics. 42(Mar 1986): 73-84, Mar 1986

        Frome, E. L., Checkoway, H. Epidemiologic programs for computers and calculators. Use of Poisson regression models in estimating incidence rates and ratios. American Journal of Epidemiology. 121(Feb 1985): 309-23, Feb 1985

        Frome, E. L. The analysis of rates using Poisson regression models. Biometrics. 39(Sep 1983): 665-74, Sep 1983

        DuFrain, R. J., Littlefield, L. G., Wilmer, J. L., Frome, E. L. Evaluation of chemically induced cytogenetic lesions in rabbit oocytes. II. A comparison of streptonigrin effects on somatic and germ cells. Mutation Research. 94(May 1982): 103-14, May 1982

        Frome, E. L. Fisher's Exact Variance Test for the Poisson Distribution. Applied Statistics. 31(1982): 67-71, 1982

        Polednak, A. P., Frome, E. L. Mortality among men employed between 1943 and 1947 at a uranium-processing plant. Journal of Occupational Medicine. 23(Mar 1981): 169-78, Mar 1981

        Frome, E. L., Khare, M. Comments on Brodsky's statistical methods for evaluating epidemiological results [letter]. Health Physics. 39(Oct 1980): 695-9, Oct 1980

        DuFrain, R. J., Littlefield, L. G., Joiner, E. E., Frome, E. L. Human cytogenetic dosimetry: a dose-response relationship for alpha particle radiation from 241Am. Health Physics. 37(Sep 1979): 279-89, Sep 1979

        Yakatan, G. J., Frome, E. L., Leonard, R. G., Shah, A. C., Doluisio, J. T. Bioavailability of acetazolamide tablets. Journal of Pharmaceutical Sciences. 67(Feb 1978): 252-6, Feb 1978

        Yakatan, G. J., Smith, R. B., Frome, E. L., Doluisio, J. T. Pharmacokinetics of orally administered hydroflumethiazide in man. Journal of Clinical Pharmacology. 17(Jan 1977): 37-47, Jan 1977

        Armstrong, R. D., and Frome, E. L. A Special Pupose Linear Programming Algorithm for Obtaining Least Absolute Value Estimators in a Linear Model with Dummy Variables. Commun. Stat. B6(4)(1977): 383-398, 1977

        Frome, E. L., Frederickson, E. L., Lushbaugh, C. C. Power spectrum of the respiratory system. Biometrics. 32(Jun 1976): 423-8, Jun 1976

        Charnes, A., Frome, E. L. and Yu, P. L. The Equivalence of Generalized Least Squares and Maximum Likelihood Estimation in the Exponential Family. Journal of The American Statistical Association. 71(1976): 169-172, 1976

        Armstrong, R. D. and Frome, E. L. A Branch and Bound Solution of a Restricted Least Squares Problem. Tecometrics. 18(1976): 447-450, 1976

        Armstrong, R. D., and Frome, E. L. A Comparison of Two Algorithms for Absolute Deviation Curve Fitting. Journal of The American Statistical Association. 71(1976): 328-330, 1976

        Frome, E. L., Frederickson, E. L. Digital spectrum analysis of the first and second heart sounds. Computers and Biomedical Research. 7(Oct 1974): 421-31, Oct 1974

        Frome, E. L. Algorithm AS 73: Cross-Spectrum Smoothing Via the Finite Fourier Transform. Applied Statistics. 23(1974): 238-244, 1974

        Frome, E. L., Kutner, M. H., and Beauchamp, J. J. Regression Analysis of Poisson-Distributed Data. Journal of The American Statistical Association. 68(1973): 935-940, 1973

        Lushbaugh, C. C., Frome, E. L., Davis, H. T., Bibler, D. S. Clinical aviation and aerospace medicine. Power spectrum of the impedance pneumograph: a data reduction system producing an analytical parameter of potential clinical usefulness. Aerospace Medicine. 40(Apr 1969): 425-9, Apr 1969

        Frome, E. L., Beauchamp, J. J. Maximum likelihood estimation of survival curve parameters. Biometrics. 24(Sep 1968): 595-605, Sep 1968