Identification of an Abnormal Beryllium Lymphocyte Proliferation Test

- Fig1.pdf
Histograms and Normal Q-Q Plots PHA: Log and Linear Scale

The panels on the left show the histograms of the SIs. The top left is for Ln(SI)s and the bottom left is for the SIs. The panels on the right are normal q-q plots. If the data in the histogram (on the left) is normally distributed then the normal q-q plot (on the right) should look like a straight line. These plots clearly show that Ln(SI)s follow the normal distribution,i.e. the SIs follow the lognormal distribution. - Fig2.pdf
Histograms and Normal Q-Q Plots ConA: Log and Linear Scale

The panels on the left show the histograms of the SIs. The top left is for Ln(SI)s and the bottom left is for the SIs. The panels on the right are normal q-q plots. If the data in the histogram (on the left) is normally distributed then the normal q-q plot (on the right) should look like a straight line. These plots clearly show that Ln(SI)s follow the normal distribution,i.e. the SIs follow the lognormal distribution. - Fig3.pdf
Histograms of the SIs for the beryllium workers and nonexposed
BeLPTs. Numbers in parenthesis are the outlier restiant median(M)
estimate of location and S the MAD estimate of the scale
parameter. The mean and standard deviation (SD) for each
distribution are also given.
- Fig4.pdf
Histograms of the Ln(SI)s for the beryllium workers and nonexposeds
BeLPTs. The outlier restiant estimates on the Ln scale of location M
(the median) and S the MAD estimate of the scale parameter for each
distribution are given in parenthesis.
- Fig5.pdf
Normal q-q plots of Ln(si)s for each beryllium concentration on day 5
and day 7 for beryllium workers and nonexposed controls. The data
values are shown on the vertical axis. The median (M), MAD scale
estimate(S) of the Ln(si)s and exp(M) are listed on each plot. Values
of M and S for beryllium workers (circles) are in upper left and
nonexposed controls (triangles) are in lower right of each panel.
- Fig6.pdf
Histogram and Normal Q-Q Plots for Ln(SImax) for beryllium workers and
nonexposed combined. The Median (M), and MAD scale estimate(S) of the
Ln(SI)s are shown.
- Fig7.pdf
Boxplots (left panel) and normal q-q plots (right panel) for
Ln(SImax). In the right panel summary statistics for nonexposed
controls (circles) are shown in lower right, and for beryllium workers
(triangles) in upper left of q-q plot. A small P value for
Kolmogorov-Smirnov (KS) goodness-of-fit test indicates departure from
normal distribution for LN(SImax).
- Fig8.pdf Empirical ROC curves for Ln(SI)s for Each Beryllium Concentration on Day 5 and Day 7. AUC is the area under the curve. The partial AUC shown in each plot is based on a nonpametric estimate of the area under the ROC curve from 0 to 0.05 on the x-axis (i.e., maximum FPR of practial interest is 0.05).

*Last Modified 10 May 2002 E. L. Frome (touches: 230590 )***Under construction for U. S. DOE, Office of Occupational Safety and Medical Surveillance(EH-61)**