## E. L. FROME'S PUBLICATIONS Supported by ORAU/DOE-ESH

Frome, E. L. and Beauchamp, J. J. (1968), "Maximum Likeli- hood Estimation of Survival Curve Parameters," Biometrics, 24, 595-605. Lushbaugh, C. C., Frome, E. L., Davis, H. T., and Bibler, D. S. (1969), "Power Spectrum of the Impedance Pneumograph: A Data Reduction System Producing an Analytical Parameter of Potential Clinical Usefulness," Aerospace Medicine, 30, 425-429. Ricks, R. C., Lushbaugh, C. C., McDow, E., and Frome, E. (1972), "Pulmonary- Impedance Power Spectral Analysis: A Facile Means of Detecting Radiation- Induced Gastrointestinal Distress and Performance Decrement in Man," Proceedings of the National Symposium on Natural and Man-made Radiation in Space, ed., E. A. Warman, NASA TM X-2440. Frome, E. L., Kutner, M. H., and Beauchamp, J. J. (1973), "Regression Analysis of Poisson-Distributed Data," Journal of The American Statistical Association, 68, 935-940. Frome, E. L., Frederickson, E. L., and Ricks, R. C. (1973), "Power Spectrum of the Respiratory System Via the Pulmonary Im- pedance Pneumograph," In: Proc. Tenth Symposium on Biomathemat- ics and Computer Science in the Life Sciences, 8-9. Frome, E. L.(1974), "Algorithm AS 73: Cross-Spectrum Smoothing Via the Finite Fourier Transform," Applied Statistics, 23, 238-244. Frome, E. L., and Frederickson, E. L. (1974), "Digital Spec- trum Analysis of The First and Second Heart Sounds," Computers and Biomedical Research . 7, 421-432. Charnes, A., Frome, E. L. and Yu, P. L. (1976). "The Equivalence of Generalized Least Squares and Maximum Likelihood Estimation in the Exponential Family," Journal of The American Statistical Association, 71: 169-172. Frome, E. L., Frederickson, E. L. and Lushbaugh, C. C. (1976). "Power Spectrum of the Respiratory System," Biometrics, 32: 423-428. DuFrain, R. J., Littlefield, L. G., Joiner, E. E., and Frome, E. L. (1979), "Human Cytogenetic Dosimetry: A Dose Response Relationship for Alpha Particle Radiation from Americium-241," Health Physics, 37, 279-289. Frome, E. L., and DuFrain, R. D. (1979), "Estimation of the Amount of Exposure to an Environmental Clastogen Using Human Cytogenetic Dosimetry," Proceedings of the 1978 DOE Statistical Symposium, November 1-3, Albuquerque, NM, 169-172. DuFrain, R. J., Littlefield, L. G., Joiner, E. E., and Frome, E. L. (1980), "In Vitro Human Cytogenetic Dose Response Systems," The Medical Basis for Radiation Accident Preparedness, Proc. Int. Conf. Oak Ridge, TN 1979, eds., K. F. Hubner and S. A. Fry, 357-374. Frome, E. L., and Hudson, D. R. (1980), "A Jackknife Pro- cedure for Estimating Standardized Mortality Ratios," Proceedings of the American Statistical Association, Computing Section, Au- gust 13-16, Washington, DC, 323-327. Frome, E. L., and Khare, M. (1980), "Comments on Brodsky's Statistical Methods for Evaluating Epidemiological Results (Letter to the Editor)," Health Phys., 39, 695-697. Frome, E. L., and Yakatan, G. J. (1980), "Statistical Esti- mation of the Pharmacokinetic Parameters in the One-Compartment Open Model," Commun. Stat., B9(3), 201-222. Polednak, A. P., and Frome. E. L (1980), "Mortality Among Men Employed (Between 1943 and 1947) at a Uranium-Processing Plant," Proceedings of the 1979 DOE Statistical Symposium, Gatlinburg, TN, 116-127. Armstrong, R. D., Frome, E. L., and Sklar, M. G. (1981), "Linear Programming in Exploratory Data Analysis," Journal of Educational Statistics, 5, 293-308. Frome, E. L. (1981), "Poisson Regression Analysis," The American Statistician, (35: 262-263). Frome, E. L. (1981), AS335: A Remark on AS 73: Cross- Spectrum Smoothing via the Finite Fourier Transform," Applied Statistics, 30, 354. Frome, E. L., and Hudson, D. R. (1981), "A General Statisti- cal Data Structure for Epidemiologic Studies of DOE Workers," Proceedings of the 1980 DOE Statistical Symposium, October 29-31, Oakland/Berkeley, CA, 206-218. Frome, E., and Hudson, D. (1981), "Interval Estimation for X-Predictions When the Dependent Variable Follows the Poisson Distribution," Proc. of the Am. Stat. Assoc., Statistical Comput- ing Section, August 11-14, Houston, TX, 294-297. Polednak, A. P., and Frome, E. L. (1981), "Mortality Among Men Employed Between 1943 and 1947 at a Uranium-Processing Plant," Journal of Occupational Medicine , 23, 169-178. DuFrain, R. J., Littlefield, L. G., Wilmer, J. L, and Frome, E. L. (1982), "Evaluation of Chemically Induced Cytogenetic Le- sions in Rabbit Oocytes, II, A Comparison of Streptonigrin Ef- fects on Somatic and Germ Cells," Mutation Research, 94: 103-114. Frome, E. L. (1982), "Fisher's Exact Variance Test for the Poisson Distribution," Applied Statistics, 31: 67-71. Littlefield, L. G., Colyer, S. P., Joiner, E. E., DuFrain, R. J., Frome, E. L., and Cohen, M. M. (1982), "Chromosomal Radia- tion Sensitivity in Ataxia Telangiectasia Long-Term, Lymphoblas- toid Cell Lines," Cytogenetics and Cell Genetics, 31: 203-213. Frome, E. L. (1983), "The Analysis of Rates Using Poisson Regression Models," Biometrics,39: 665-674. Lushbaugh, C. C., Fry, S. A., Shy, C. M. and Frome, E. L. (1983), "DOE Health and Mortality Study at Oak Ridge," In: Health Physics Society: Epidemiology Applied to Health Physics, Proceedings of the Sixteenth Midyear Topical Symposium, U.S. Department of Energy Report, CONF-830101, pp. 105- 114, Albu- querque, NM 1983. Frome, E. L. and McLain, R. (1984), "A SAS Macro for Fitting Nonlinear Models to Poisson Distributed Data," In: Proceedings of the Ninth Annual SUGI Conference, Hollywood Beach, Florida, pp. 883-883. Frome, E. L. (1984), "Response to Nelder's Reaction on Pois- son Rate Analysis," Biometrics, 40: 1160-1162. Frome, E. L. and Checkoway, H. (1985), "The Use of Poisson Regression Models in Estimating Incidence Rates and Ratios," American Journal of Epidemiology, 309-323. Frome, E. L. (1986), "Regression Methods for Binomial and Poisson Distributed Data," In: Proceedings of American Associa- tion of Physicists in Medicine First Midyear Topical Symposium on Multiple Regression Analysis, Applications in the Health Sci- ences, Herbert, D., and Meyers, R., eds., The American Institute of Physics, New York, 84-123. Frome, E. L. and DuFrain, R. J. (1986), "Maximum Likelihood Estimation for Cytogenetic Dose-Response Curves," Biometrics, 42: 73-84 . McLain,R. and Frome,E.L. (1986),"A System for the Analysis of Cohort Mortality Data",in SAS Users Group International Proceedings,874-876. Littlefield, L.G., Joiner, E.E., Colyer, S.P., and Frome, E.L., (1987), "Effects of Cryopreservation on the Recovery of Radiation-Induced Chromosome Aberrations in Human Lymphocytes," Radiation Protection Dosimetry Journal,18: 25-29. Carpenter,A.V., Flanders,W.D., Frome,E.L., Crawford- Brown,D.J., and Fry,S.A. (1987), "Central Nervous System Cancers and Radiation Exposures: A Case-Control Study Among Workers at Two Nuclear Facilities," Journal of Occupational Medicine,29: 601-604. Carpenter,A.V., Flanders,W.D., Frome,E.L., Cole,P.,and Fry,S.A. (1987), "Brain Cancer and Non-occupational Risk Factors : A Case-Control Study Among Workers at Two Nuclear Facilities," The American Journal of Public Health,77: 1180-1182. Littlefield, L.G.,Joiner,E.E ,Colyer,S.P., Sayer,A.M. and Frome,E.L.(1988), "Modualtion of Radiation-Induced Chrosome Aber- rations By DMSO- An OH Radical Scavenger," The International Journal of Radiation Biology ,53: 875-890. Carpenter,A.V., Flanders,W.D., Frome,E.L., Tankersley, W.G.,and Fry,S.A. (1988), "Chemical Exposures and Central Nervous System Cancers: A Case-Control Study Among Workers at Two Nuclear Facilities," The American Journal of Industrial Medicine,13:351- 362. Frome, E. L., and Morris, M. D. (1989), "Evaluating Goodness of Fit of Poisson Regression Models in Cohort Studies",The Ameri- can Statistician,43:144-147. Littlefield, L. G., Sayer, A. M.,and Frome, E. L. (1989), "Comparisons of Dose Response Parameters For Radiation-Induced Acentric Fragments and Micronuclei Observed in Cytokinesis- Arrested Lymphocytes", Mutagenesis,4:265-270. Ostrouchov, G. and Frome, E. (1989), "A Model Search Pro- cedure for Hierarchical Log-Linear Models",Proceedings Of Sta- tistical Computing Section of American Statistical Assoc,277-282. Frome, E.L., Cragle ,D.L., and McLain,R. (1990), "Poisson Regression Analysis of The Morality Among a Cohort of World War II Nuclear Industry Workers ", Radiation Research,123:138-152. Frome, E. L., (1991), "Statistical Analysis of Cytogenetic Dose-Response Curves," in Statistical Methods in Toxicological Research, eds. D. Krewski and C. Franklin, Gordon & Breach Sci- ence Publications, Inc., 281-298. Wing,S., Shy,C.M., Wood,J., Wolf, S., Cragle, D.,and Frome, E.(1991), "Mortality Among Workers at Oak Ridge National Labora- tory: Evidence of Radiation Effects in Follow-up Through 1984" Journal of The American Medical Association,256:1397-1402. Littlefield,L.G., Sayer,A.M., Sallam,F., Frome,E.L., and Kleinerman,R.A., (1992),"Experience With The Cytochalasin-B Method for Quantifing Radiation Induced Micronuclei in Human Lym- phocytes" ,Proc. International Congress of Radiation Research, Toronto, Canada, pp 183-188. Ostrouchov, G. and Frome, E. (1993), "A Model Search Pro- cedure for Hierarchical Models",Computational Statistics and Data Analysis, 15, 285-296. Littlefield, L.G.,Joiner,E.E ,Colyer,S.P.,Sallam,F., and Frome,E.L.(1993), "Concentration Dependent Protection Against X- ray Induced Chromosome Aberrations in Human Lymphocytes by The Aminothiol WR-1065" Radiation Research 133, 88-93. Wing,S., Shy,C.M., Wood,J., Wolf, S., Cragle, D.,and Frome, E. (1993), "Job Factors, Radiation and Cancer Mortality at Oak Ridge National Laboratory: Follow-up Through 1984",American Jour- nal of Industrial Medicine 23, 265-279. Watkins, J. ,Regan,J.,Cragle,D., Frome,E. et al (1993) "Data Collection, Validation, and Description For The Oak Ridge Nuclear Facilities Mortality Study",Technical Report ORISE 93/J-42 Mitchell,T.J., Ostrouchov,G., Frome, E. and Kerr, G. (1993),"A Method For Estimating Occupational Dose To Individuals, Using Weekly Dosimetry Data", ORNL 6778 , pp 1-41. Frome,E.L., Smith,M.,Littlefield,G.,Neubert,R. and Colyer,S. (1994) , "Statistical Methods For The Analysis of a Screening Test For Chronic Beryllium Disease", ORNL-6818 ), pp 1-61. Littlefield, L.G.,Joiner,E.E, Colyer,S.P.,andFrome,E.L.(1994), "Radioprotective Chemicals as Tools for Study-ing Mechanisms of Radiation-Induced Chromosome Damage in Human Lymphocytes" in Chromosomal Alterations, eds. G. Obe and A. T. Natarajan,Springer-Verlag,New York, pp 132-139. Fry SA, Cragle DL, Crawford-Brown DJ, Dupree EA, Frome EL, Gilbert ES, Petersen GR, Shy CM, Tankersley WG, Voelz GL, Wallace PW, Watkins JP, Watson Jr. JE, and Wiggs LD (1995), "Health and Mortality Among Contractor Employees at US Department of Energy Facilities", in Radiation and Public Perception Benefits and Risks, Advances in Chemistry Series, eds.Young JP and Yalow RS, American Chemical Society, Washington, DC, 239-258. Frome,E.L., Smith,M.,Littlefield,G.,Neubert,R. and Colyer,S. (1996) , "Statistical Methods for the Blood Beryllium Lymphocyte Proliferation Test ", Environmental Health Perspectives, Vol 105, Supplement 5,957-968 . Frome, E.L., Cragle, D.L., Watkins, J., Wing, S., Shy, S., Tankersley, W., and West, C. (1997), "A Mortality Study of Em- ployees of the Nuclear Industry in Oak Ridge, Tennessee", ORNL- 6785, pp 1-67.(See http://www.epm.ornl.gov/~frome/ORMS/) Watkins,J.P., Reagan, J.L., Cragle, D.L.,Frome, E.L., West, C.M., Crawford-Brown,D. , and Tankersley, W.G. (1997), "Collec- tion, Validation, and Treatment of Data for a Mortality Study of Nuclear Industry Workers ", Applied Occupational and Environmen- tal Hygiene ,12(3), 195-205. Frome,E.L., L.S. Newman, and M. M. Mroz (1997) ," Results of the Analysis of The Blood Lymphocyte Proliferation Test Data From The National Jewish Center", ORNL/TM-13338, pp 1-36 Frome, E.L., Cragle, D.L., Watkins, J., Wing, S., Shy, S., Tankersley, W., and West, C. (1997), "A Mortality Study of Employees of the Nuclear Industry in Oak Ridge, Tennessee", Radiation Research,148,64-80. Mitchell,T.J., Ostrouchov,G., Frome, E. and Kerr, G. (1997),"A Method For Estimating Occupational Dose To Individuals, Using Weekly Dosimetry Data", Radiation Research,147:195-207. Frome, E.L., Watkins, J.P. (1998)"Statistical Issues in Radiation Dose-Response Analysis of Employees of the Nuclear Industry in Oak Oak Ridge, Tennessee", Proceedings of the American Statistical Association, Statistic In Epidemiology Section, 58-63. Frome, E. L. Strader, C. H. Dupree, E.A. Stockwell,H. G.(2000), "Relative Risk Estimation for Occupational Groups in Epidemiologic Surveillance", Proceedings of the American Statistical Association, Statistic In Epidemiology Section. Ostrouchov,G., Frome, E. and Kerr, G.(2000),"Dose Estimation from Daily and Weekly Dosimetry Data", ORNL/TM-1999/282, pp 1-30. Farris,G.M. Newman,L.S., Frome, et al (2000), "Detection of Beryllium Sensitivity Using a Flow Cytometric Lymphocyte Proliferation Test: the IMMUNO-BE-LPT", Toxicology,143:125-140. Frome, E.L., D. L. Cragle, L. G Littlefield, and S. P. Colyer,(2001) "Results of the Analysis of The Blood Beryllium Lymphocyte Proliferation Test Data From The Oak Ridge Y-12 Study", ORNL/TM-2001/79, pp 1-27. Frome, E.L., D. L. Cragle, S. P. Colyer, and P. F. Wambach, (2002) "Development and Evaluation of a Screening Test for Beryllium Sensitization", Proceedings of the American Statistical Association, Statistic In Epidemiology Section. Frome,E.L. Newman, L.S., Cragle, D.L, Colyer, S.P. and P.F. Wambach (2003)",Identification of an Abnormal Beryllium Lymphocyte Proliferation Test", Toxicology,183:39-56.(http://www.csm.ornl.gov/~frome/toxsbp/) Frome, E. L., and P. G. Groer, (2004), Individual Dose Adjustment Procedure for Y-12 Dose Reconstruction, ORAUT-TIB-0013, Revision No. 00-A, Oak Ridge Associate Universities, Oak Ridge, Tennessee Frome, E. L. and J. Watkins, (2004), Statistical Analysis of Data with Non-detectable Values,ORNL/TM-2004/146. (http://www.csm.ornl.gov/~frome/sand/) Kerr, G.D., J.P.Watkins, E.L. Frome, and W. G. Tankersley, "Historical Evaluation of the Film Badge Dosimetry Program at the Y-12 Facility in Oak Ridge, Tennessee: Part 1 - Gamma Radiation" ORAUT-OTIB-0044 ( 2005 Under review by NIOSH) Kerr, G.D. , E.L. Frome, W. G. Tankersley, and J. P. Watkins, "Historical Evaluation of the Film Badge Dosimetry Program at the Y-12 Facility in Oak Ridge, Tennessee: Part 2 Neutron Radiation", ORAUT-OTIB-0045 ( 2005 Under review by NIOSH) E. L. Frome and P. F. Wambach,(June,2005),"Statistical Methods and Software for the Analysis of Occupational Exposure Data With Non-Detectable Values" ORNL/TM-2005/52 (http://www.csm.ornl.gov/esh/aoed/)