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The three exposure analysis files at the top of
Figure A1 contain the
external dose estimate, and the internal exposure index for each year
that a person worked at X-10, Y-12, or K-25. In addition to the usual
time related variables encountered in occupational cohort
studies (i.e. birth cohort, age at risk) there were three time
dependent covariates:
- cumulative external dose in year t
- sequential internal exposure category in year t
- facility in year t (as described at the beginning of the
Appendix)
The entry and exit dates for the time dependent cells also include a
lag of two, ten, or twenty years. The person-epoch [3] approach with
grouping on the time dependent covariates is used to generate the ADS
shown at the bottom of Figure A1 .
The factors in Table AIII are used
to illustrate the procedure that was followed to generate the ADS for
our dose-response analysis.
