In the late 1960s the development of high speed digital computers and
analog to digital converters opened a new era in signal processing,
since it was then possible to sample biologic time series at the rate
of thousands of points per second. This new technology required new
methods of statistical analysis. A physiologically based mechanical
model of the respiratory system was developed and used to motivate the
definition of the power spectrum for pulmonary time series data
(Frome,Frederickson, and Lushbaugh,1976). New statistical methods
based on numeric spectrum analysis were developed and applied to the
analysis of pulmonary impedance data that is used to monitor the
respiratory function of remotely located persons---see Lushbaugh,
Frome et al(1969), Frome(1974).
A second area of application digital spectrum analysis was to the
first and second heart sounds during open heart surgery---Frome and
Frederickson(1974).
Last Modified 22Nov97FromeEL@ORNL.gov
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