Frome, E. L. and Beauchamp, J. J. (1968),  "Maximum  Likeli-
hood  Estimation  of  Survival Curve Parameters," Biometrics, 24,
595-605.

     Frome, E. L., Kutner, M. H., and Beauchamp,  J.  J.  (1973),
"Regression Analysis of Poisson-Distributed Data," Journal of The
American Statistical Association, 68, 935-940.

     Charnes, A., Frome, E.  L.  and  Yu,  P.  L.  (1976).   "The
Equivalence  of  Generalized Least Squares and Maximum Likelihood
Estimation in the Exponential Family," Journal  of  The  American
Statistical Association, 71: 169-172.

     DuFrain, R. J., Littlefield,  L.  G.,  Joiner,  E.  E.,  and
Frome,  E.  L.  (1979),  "Human  Cytogenetic  Dosimetry:   A Dose
Response  Relationship  for   Alpha   Particle   Radiation   from
Americium-241," Health Physics, 37, 279-289.

     Frome, E. L., and DuFrain, R. D. (1979), "Estimation of  the
Amount  of  Exposure  to  an  Environmental Clastogen Using Human
Cytogenetic Dosimetry," Proceedings of the 1978  DOE  Statistical
Symposium, November 1-3, Albuquerque, NM, 169-172.

     DuFrain, R. J., Littlefield,  L.  G.,  Joiner,  E.  E.,  and
Frome,  E.  L.  (1980), "In Vitro Human Cytogenetic Dose Response
Systems," The Medical Basis for Radiation Accident  Preparedness,
Proc. Int. Conf. Oak Ridge, TN 1979, eds., K. F. Hubner and S. A.
Fry, 357-374.

     Frome, E. L.  (1981),  "Poisson  Regression  Analysis,"  The
American Statistician, (35: 262-263).

     Frome, E. L., and Hudson, D. R. (1981), "A General Statisti-
cal  Data  Structure  for  Epidemiologic Studies of DOE Workers,"
Proceedings of the 1980 DOE Statistical Symposium, October 29-31,
Oakland/Berkeley, CA, 206-218.

     Frome, E., and Hudson, D. (1981), "Interval  Estimation  for
X-Predictions  When  the  Dependent  Variable Follows the Poisson
Distribution," Proc. of the Am. Stat. Assoc., Statistical Comput-
ing Section, August 11-14, Houston, TX, 294-297.


     DuFrain, R. J., Littlefield, L. G., Wilmer, J. L, and Frome,
E.  L.  (1982), "Evaluation of Chemically Induced Cytogenetic Le-
sions in Rabbit Oocytes, II, A Comparison  of  Streptonigrin  Ef-
fects on Somatic and Germ Cells," Mutation Research, 94: 103-114.

     Frome, E. L. (1982), "Fisher's Exact Variance Test  for  the
Poisson Distribution," Applied Statistics, 31: 67-71.

     Littlefield, L. G., Colyer, S. P., Joiner, E.  E.,  DuFrain,
R. J., Frome, E. L., and Cohen, M. M. (1982), "Chromosomal Radia-
tion Sensitivity in Ataxia Telangiectasia Long-Term,  Lymphoblas-
toid Cell Lines," Cytogenetics and Cell Genetics, 31: 203-213.

     Frome, E. L. (1983), "The Analysis of  Rates  Using  Poisson
Regression Models," Biometrics,39: 665-674.

     Lushbaugh, C. C., Fry, S. A., Shy, C. M. and  Frome,  E.  L.
(1983),  "DOE  Health  and  Mortality  Study  at  Oak Ridge," In:
Health Physics Society:  Epidemiology Applied to Health  Physics,
Proceedings  of  the  Sixteenth  Midyear  Topical Symposium, U.S.
Department of Energy Report, CONF-830101,  pp.  105-  114,  Albu-
querque, NM 1983.

     Frome, E. L. and McLain, R. (1984), "A SAS Macro for Fitting
Nonlinear  Models  to Poisson Distributed Data," In:  Proceedings
of the Ninth Annual SUGI Conference,  Hollywood  Beach,  Florida,
pp. 883-883.

     Frome, E. L. (1984), "Response to Nelder's Reaction on Pois-
son Rate Analysis," Biometrics, 40: 1160-1162.

     Frome, E. L. and Checkoway, H. (1985), "The Use  of  Poisson
Regression  Models  in  Estimating  Incidence  Rates and Ratios,"
American Journal of Epidemiology, 309-323.

     Frome, E. L. and DuFrain, R. J. (1986), "Maximum  Likelihood
Estimation for Cytogenetic Dose-Response Curves," Biometrics, 42:
73-84 .

     McLain,R. and Frome,E.L. (1986),"A System for  the  Analysis
of  Cohort  Mortality  Data",in  SAS  Users  Group  International
Proceedings,874-876.

     Littlefield, L.G., Joiner, E.E., Colyer,  S.P.,  and  Frome,
E.L.,  (1987),  "Effects  of  Cryopreservation on the Recovery of
Radiation-Induced Chromosome Aberrations in  Human  Lymphocytes,"
Radiation Protection Dosimetry Journal,18: 25-29.

     Littlefield, L.G.,Joiner,E.E  ,Colyer,S.P.,  Sayer,A.M.  and
Frome,E.L.(1988), "Modualtion of Radiation-Induced Chrosome Aber-
rations By DMSO- An  OH  Radical  Scavenger,"  The  International
Journal of Radiation Biology ,53: 875-890.

     Frome, E. L., and Morris, M. D. (1989), "Evaluating Goodness
of Fit of Poisson Regression Models in Cohort Studies",The Ameri-
can Statistician,43:144-147.

     Littlefield, L. G., Sayer, A. M.,and Frome,  E.  L.  (1989),
"Comparisons  of  Dose  Response Parameters For Radiation-Induced
Acentric  Fragments  and  Micronuclei  Observed  in  Cytokinesis-
Arrested Lymphocytes", Mutagenesis,4:265-270.

     Frome, E.L., Cragle ,D.L., and  McLain,R.  (1990),  "Poisson
Regression  Analysis  of The Morality Among a Cohort of World War
II Nuclear Industry Workers ", Radiation Research,123:138-152.

     Frome, E. L., (1991), "Statistical Analysis  of  Cytogenetic
Dose-Response  Curves,"  in  Statistical Methods in Toxicological
Research, eds. D. Krewski and C. Franklin, Gordon &  Breach  Sci-
ence Publications, Inc., 281-298.

     Wing,S., Shy,C.M., Wood,J., Wolf, S., Cragle, D.,and  Frome,
E.(1991),  "Mortality Among Workers at Oak Ridge National Labora-
tory: Evidence of Radiation Effects  in Follow-up  Through  1984"
Journal of The American Medical Association,256:1397-1402.

    Littlefield,L.G.,  Sayer,A.M.,  Sallam,F.,  Frome,E.L.,  and
Kleinerman,R.A.,   (1992),"Experience   With  The  Cytochalasin-B
Method for Quantifing Radiation Induced Micronuclei in Human Lym-
phocytes"  ,Proc.  International  Congress of Radiation Research,
Toronto, Canada, pp 183-188.

     Ostrouchov, G. and Frome, E. (1993), "A  Model  Search  Pro-
cedure for Hierarchical Models",Computational Statistics and Data
Analysis, 15, 285-296.

     Littlefield,  L.G.,Joiner,E.E  ,Colyer,S.P.,Sallam,F.,   and
Frome,E.L.(1993),  "Concentration Dependent Protection Against X-
ray Induced Chromosome Aberrations in Human  Lymphocytes  by  The
Aminothiol WR-1065" Radiation Research 133, 88-93.

     Wing,S., Shy,C.M., Wood,J., Wolf, S., Cragle, D.,and  Frome,
E.  (1993),  "Job  Factors, Radiation and Cancer Mortality at Oak
Ridge National Laboratory: Follow-up Through 1984",American Jour-
nal of Industrial Medicine  23, 265-279.

     Littlefield, L.G.,Joiner,E.E ,Colyer,S.P., and Frome,E.L.
(1994),  "Radioprotective Chemicals as Tools for Study-
ing Mechanisms of Radiation-Induced Chromosome  Damage  in  Human
Lymphocytes"  in  Chromosomal  Alterations, eds. G. Obe and A. T.
Natarajan,Springer-Verlag,New York, pp 132-139.


     Fry SA, Cragle DL, Crawford-Brown DJ, Dupree EA,  Frome  EL,
Gilbert ES, Petersen GR, Shy CM, Tankersley WG, Voelz GL, Wallace
PW, Watkins JP, Watson Jr. JE, and Wiggs LD (1995),  "Health  and
Mortality  Among  Contractor Employees at US Department of Energy
Facilities", in Radiation  and  Public  Perception  Benefits  and
Risks,  Advances  in Chemistry Series, eds.Young JP and Yalow RS,
American Chemical Society, Washington, DC, 239-258.


     Frome, E.L., Cragle, D.L., Watkins, J., Wing, S.,  Shy,  S.,
Tankersley,  W.,  and West, C. (1997), "A Mortality  Study of Em-
ployees of the Nuclear Industry in Oak Ridge,  Tennessee",  ORNL-
6785, pp 1-67.(See http://www.epm.ornl.gov/~frome/ORMS/)

    Frome, E.L., Cragle, D.L., Watkins, J., Wing, S.,  Shy,  S.,
Tankersley,  W.,  and West, C. (1997), "A Mortality  Study of 
Employees  of the  Nuclear Industry in Oak Ridge, Tennessee",
Radiation Research,148,64-80.

     Frome, E.L., Watkins, J.P. (1998) "Statistical Issues in Radiation
Dose-Response Analysis of Employees of the Nuclear Industry in Oak Oak
Ridge, Tennessee" Proceedings of the 1997 American Statistical
Association, Statistic In Epidemiology Section, 58-63.

Last Modified 4 Feb 1999FromeEL@ORNL.gov (touches: 9865 )