ORNL: Science & Technology: Simulation Science: Computational Biology and Functional Genomics

OAK RIDGE NATIONAL LABORATORY

Computational Biology and Functional Genomics

ORNL's life sciences research covers all aspects of biology from the building blocks of life, DNA, genes and proteins, to the health and fitness of humans, using a sophisticated mosaic of advanced computing,and laboratory research.

History

ORNL's strong involvement in biological research began in the 1940's with the Mammalian Genetics program and grew to include computational biology in the 1960's, when mathematical calculations began to be used to model human "phantoms".

Virtual Human History (SC98 exhibit)
Computing the Genome Revolution: Biology for the 21st Century (SC98 exhibit)
Accelerating the Genome Revolution: Biology for the 21st Century (SC99 exhibit)

Research

In order to understand complete biological systems, from the molecular level to the functional organism, ORNL has launched an initiative in complex biological systems. To meet this challenge, research teams are drawn from the broad range of disciplines available across the laboratory.

Virtual Human Program
The Virtual Human Project: An Idea Whose Time Has Come? (ORNL Review)
Virtual Human Initiative (SC99 exhibit)
Life Sciences Division (LSD)
    Human Genome Project
    ORNL Center for Biokinetic and Dosimetric Research
LSD Computational Protein Structure Group
Joint Institute for Biological Sciences
Genome Science & Technology Graduate Program of UT and ORNL

Resources

In addition to massive data repositories, widely-used computational tools, and innovative technology developments, ORNL is home to unique experimental facilities.

Biosensors for Biotechnology (DNA Biochip)
GRAIL, GenQuest, and other tools
Life Sciences Division (LSD)
    The Genome Channel
    PROSPECT (PROtein Structure Prediction and Evaluation Computer Toolkit)
LSD Mammalian Genetics & Development Section
     Mouse Genetics Research Facility (MGRF)
     Mutant Mouse Database
    ORNL Center for Biokinetic and Dosimetric Research